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122 products · 249 listings

153 products · 275 listings
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FROM PEPTIDES CALCULATOR
Source profile reviewed 2026-10-01 · Imported 2026-10-22. Read the full compound profile
Epithalon, also written Epitalon, is the synthetic tetrapeptide Ala-Glu-Asp-Gly. Vladimir Khavinson's group at the St Petersburg Institute of Bioregulation and Gerontology assembled it from the amino acid composition of epithalamin, a low molecular weight peptide extract of cattle pineal glands, and reported detecting the same sequence inside a pineal polypeptide complex in 2017. Almost the whole literature comes from that one institute and is in cell culture, fruit flies, mice, rats and two short monkey experiments, where it is described as inducing telomerase, shifting gene expression and restoring evening melatonin in old animals, while a direct test on perifused rat pineal glands found no effect on melatonin at all. Human work amounts to a parabulbar injection study in retinitis pigmentosa and a 20-day sublingual spray study in night-shift workers; the mortality figures quoted for elderly people came from epithalamin, the extract, which PubChem also lists as a synonym of this record. FDA evaluated it for insomnia in 2026, found no pharmacokinetic data and no clinical safety study, and proposed that neither the free base nor the acetate be added to the 503A Bulks List, while one 2026 evidence review reports that the advisory committee voted to recommend adding it anyway by the narrowest margin of the seven peptides considered.
A 2003 paper reported telomerase activation and telomere elongation in cultured human somatic cells.
A later study reported dose-dependent telomere effects across normal and cancer cell lines.
Cellular telomere findings do not show lifespan extension or clinical benefit in people.
Background is reproduced from Peptides Calculator with attribution. The source describes compound-level research. It does not evaluate the identity, quality or suitability of a listed supplier’s product or batch.