Epithalon prices

FROM PEPTIDES CALCULATOR

About Epithalon

Source profile reviewed 2026-10-01 · Imported 2026-10-22. Read the full compound profile

Epithalon, also written Epitalon, is the synthetic tetrapeptide Ala-Glu-Asp-Gly. Vladimir Khavinson's group at the St Petersburg Institute of Bioregulation and Gerontology assembled it from the amino acid composition of epithalamin, a low molecular weight peptide extract of cattle pineal glands, and reported detecting the same sequence inside a pineal polypeptide complex in 2017. Almost the whole literature comes from that one institute and is in cell culture, fruit flies, mice, rats and two short monkey experiments, where it is described as inducing telomerase, shifting gene expression and restoring evening melatonin in old animals, while a direct test on perifused rat pineal glands found no effect on melatonin at all. Human work amounts to a parabulbar injection study in retinitis pigmentosa and a 20-day sublingual spray study in night-shift workers; the mortality figures quoted for elderly people came from epithalamin, the extract, which PubChem also lists as a synonym of this record. FDA evaluated it for insomnia in 2026, found no pharmacokinetic data and no clinical safety study, and proposed that neither the free base nor the acetate be added to the 503A Bulks List, while one 2026 evidence review reports that the advisory committee voted to recommend adding it anyway by the narrowest margin of the seven peptides considered.

Formula

C14 H22 N4 O9

Molar mass

390.4 g/mol

CAS number

307297-39-8

Amino acids

4

Research evidence described in the source

Limitations noted in the source

• Most publications originate from a small interconnected research network.
• No large independently replicated randomized human trial establishes anti-aging benefit.
• Telomerase activation has context-dependent theoretical risks and is not inherently beneficial.
• A calculator preset is a recorded research convention, not a recommendation or evidence of clinical benefit.

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