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Solution Peptides
153 products · 275 listings
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KPV Atomized Solution Kit prices
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FROM PEPTIDES CALCULATOR
About KPV
Source profile reviewed 2026-10-01 · Imported 2026-10-22. Read the full compound profile
KPV is the tripeptide lysine-proline-valine, the last three residues of alpha-melanocyte-stimulating hormone and therefore also residues 11-13 of ACTH, which begins with the same 13-amino-acid sequence. Reviews from the Munster dermatology group describe it as the part of alpha-MSH that keeps the hormone's anti-inflammatory activity without its pigment-stimulating effect, and mechanistic work suggests it acts inside cells, entering through the PepT1 peptide transporter and damping NF-kB signalling rather than binding melanocortin receptors; it also inhibits Staphylococcus aureus and Candida albicans in culture. Every efficacy result comes from cell lines or from mouse and rat models of colitis, peritonitis, skin and corneal injury, including two 2008 mouse colitis studies, and the FDA's July 2026 review for compounding found no clinical study, no human exposure data and no pharmacokinetic or toxicity study in any species. KPV is sold as a research chemical and promoted by compounding and telehealth outlets as injections, capsules, creams and nasal sprays; FDA reviewers proposed against listing it for 503A compounding, the advisory committee nevertheless voted 8 to 6 to recommend it, and rulemaking had not concluded when this dossier was written.
- Formula
- C16 H30 N4 O4
- Molar mass
- 342.4 g/mol
- CAS number
- 67727-97-3
- Amino acids
- 3
Research evidence described in the source
Multiple mouse colitis models
KPV reduced selected inflammatory and histologic measures in preclinical intestinal models.
Human epithelial and immune cells
Nanomolar KPV was studied in cytokine-stimulated cell systems with PepT1-dependent uptake.
No established clinical regimen
Published evidence does not establish injectable efficacy or long-term safety in humans.
Limitations noted in the source
- Mouse colitis outcomes do not establish treatment effects in human inflammatory bowel disease.
- Oral PepT1-targeted research is not equivalent to an injectable preset.
- A calculator preset is a recorded research convention, not a recommendation or evidence of clinical benefit.
- Identity, purity, sterility, and stability can vary substantially outside regulated manufacturing.
Publications and references linked by the source
- pubchem.ncbi.nlm.nih.gov/compound/125672
- www.fda.gov/media/193346/download
- www.fda.gov/advisory-committees/advisory-committee-calendar/july-23-24-2026-meeting-pharmacy-compounding-advisory-committee-07232026
- pubmed.ncbi.nlm.nih.gov/18612139/
- pubmed.ncbi.nlm.nih.gov/12750433/
- pubmed.ncbi.nlm.nih.gov/10670585/
- pmc.ncbi.nlm.nih.gov/articles/PMC2431115/
- pubmed.ncbi.nlm.nih.gov/18092346/
Background is reproduced from Peptides Calculator with attribution. The source describes compound-level research. It does not evaluate the identity, quality or suitability of a listed supplier’s product or batch.