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FROM PEPTIDES CALCULATOR

About Livagen

Source profile reviewed 2026-10-01 · Imported 2026-10-22. Read the full compound profile

Livagen is a synthetic four-residue peptide, Lys-Glu-Asp-Ala (KEDA), from the family of short bioregulators that Vladimir Khavinson's group at the St. Petersburg Institute of Bioregulation and Gerontology designed to stand in for the active fragments of organ extracts, in this case a liver preparation. Its published record consists of culture work from that group and its Georgian collaborators, in which the peptide raised protein synthesis in hepatocytes from rats of different ages and loosened condensed chromatin in lymphocytes taken from people aged 75 to 91, together with a two-week oral rat study of digestive enzymes and an in vitro assay in which it inhibited enkephalin-degrading enzymes in human serum. The only account of human treatment is an uncontrolled 23-patient hepatitis series inside Khavinson's expired 2006 US patent; vendor research guides that queried ClinicalTrials.gov in 2026 found no registered trial, no pharmacokinetic study has been published, and no regulator has approved it. Outside Russia it is sold as a lyophilized research chemical in 5, 10 and 20 mg vials, and inside the Russian bioregulator supplement line as oral capsules.

Formula
C18 H31 N5 O9
Molar mass
461.5 g/mol
CAS number
433257-50-2
Amino acids
4

Research evidence described in the source

Not graded

DNA Organization in Eukaryotes

Understanding DNA packaging and organization in eukaryotic cells

Not graded

Chromatin's Role in Gene Expression Control

How Livagen affects chromatin structure and gene expression

Limitations noted in the source

  • Individual claims and source links have not yet completed editorial verification.
  • Evidence level, applicable study model, formulation, route and population remain unassigned.
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Background is reproduced from Peptides Calculator with attribution. The source describes compound-level research. It does not evaluate the identity, quality or suitability of a listed supplier’s product or batch.