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153 products · 275 listings
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FROM PEPTIDES CALCULATOR
Source profile reviewed 2026-10-01 · Imported 2026-10-22. Read the full compound profile
Melanotan II (MT-II) is a synthetic, cyclic seven-residue analog of the pigment hormone alpha-MSH, designed at the University of Arizona in the late 1980s as a way to induce a protective tan without ultraviolet exposure. It activates several melanocortin receptor subtypes at once, so alongside skin darkening it produces nausea, flushing, appetite suppression and spontaneous erections, the last of which led to the small erectile dysfunction trials of the late 1990s and to the development of its metabolite bremelanotide. Human data consist of a three-person phase 1 pilot, two ten-man crossover studies and a growing stack of case reports; MT-II has never been approved anywhere, is sold illegally for tanning, and was listed by the FDA among compounding substances that may present significant safety risks from 2023 until the nomination was withdrawn in April 2026.
Understanding MT-2's receptor binding and signaling mechanisms
MT-2's potential in treating Autism Spectrum Disorder
MT-2's role in appetite suppression and weight management
Background is reproduced from Peptides Calculator with attribution. The source describes compound-level research. It does not evaluate the identity, quality or suitability of a listed supplier’s product or batch.