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122 products · 249 listings

153 products · 275 listings
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FROM PEPTIDES CALCULATOR
Source profile reviewed 2026-10-01 · Imported 2026-10-22. Read the full compound profile
Orforglipron (Foundayo, development code LY3502970) is a once-daily oral GLP-1 receptor agonist, originally discovered at Chugai Pharmaceutical and out-licensed in 2018. Unlike semaglutide and tirzepatide it is not a peptide at all but a small synthetic molecule that activates the same receptor, which is why it can be swallowed as an ordinary tablet with no food, water or refrigeration restrictions. The FDA approved it in April 2026 for long-term weight management in adults with obesity, or overweight plus a weight-related condition, alongside a reduced-calorie diet and more physical activity; regulatory submissions for weight management and type 2 diabetes are pending elsewhere. Its phase 3 programme is unusually large for a new entrant, covering obesity (ATTAIN), type 2 diabetes (ACHIEVE) and ongoing trials in sleep apnoea, hypertension, osteoarthritis pain and peripheral arterial disease.
Current development stage and why no consumer dosing guide is shown
How orforglipron works as an oral GLP-1 receptor agonist
What makes it different from older oral and injectable GLP-1 options
Weight loss and glycemic-control outcomes described in the provided article
Background is reproduced from Peptides Calculator with attribution. The source describes compound-level research. It does not evaluate the identity, quality or suitability of a listed supplier’s product or batch.