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Solution Peptides
153 products · 275 listings
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PNC-27 Atomized Solution Kit prices
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FROM PEPTIDES CALCULATOR
About PNC-27
Source profile reviewed 2026-10-01 · Imported 2026-10-22. Read the full compound profile
PNC-27 is a 32-amino-acid synthetic peptide that joins residues 12 to 26 of the human p53 tumour suppressor, the part that binds the HDM-2 (MDM2) protein, to penetratin, a membrane residency sequence from the Antennapedia protein. Groups at SUNY Downstate, Drexel and collaborating institutions report that cancer cells carry HDM-2 in their plasma membrane while untransformed cells do not, and that PNC-27 binds that membrane HDM-2 and forms pores, killing the cell by necrosis rather than apoptosis; cells engineered to display HDM-2 on their surface became susceptible. The compound has been tested in cancer cell lines, patient-derived ovarian tumour cells and mouse leukaemia models, but never in a human trial, and several of its investigators hold patents or company positions. In January 2017 the FDA warned consumers not to buy or use PNC-27 as a cancer treatment after finding the bacterium Variovorax paradoxus in a sample of an inhalation solution sold online.
- Formula
- C188 H293 N53 O44 S
- Molar mass
- 4,032 g/mol
- CAS number
- 1159861-00-3
- Amino acids
- 32
Research evidence described in the source
PNC-27 Peptide
Molecular structure and properties
How Does the PNC-27 Peptide Work?
Mechanism of selective cancer cell destruction
Limitations noted in the source
- Individual claims and source links have not yet completed editorial verification.
- Evidence level, applicable study model, formulation, route and population remain unassigned.
Publications and references linked by the source
- pubchem.ncbi.nlm.nih.gov/compound/16201774
- pmc.ncbi.nlm.nih.gov/articles/PMC7951797/
- pubmed.ncbi.nlm.nih.gov/40750238/
- pubmed.ncbi.nlm.nih.gov/20182728/
- pubmed.ncbi.nlm.nih.gov/20080680/
- pmc.ncbi.nlm.nih.gov/articles/PMC9138867/
- www.fda.gov/consumers/health-fraud-scams/questions-and-answers-fda-alerts-companies-stop-illegal-sale-products-claiming-treat-cancer
Background is reproduced from Peptides Calculator with attribution. The source describes compound-level research. It does not evaluate the identity, quality or suitability of a listed supplier’s product or batch.