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Solution Peptides
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Sermorelin Atomized Solution Kit prices
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FROM PEPTIDES CALCULATOR
About Sermorelin
Source profile reviewed 2026-10-01 · Imported 2026-10-22. Read the full compound profile
Sermorelin is the first 29 amino acids of human growth hormone-releasing hormone with a C-terminal amide, the shortest fragment that keeps essentially all of the activity of the full 44-residue hormone. It stimulates the pituitary to release its own growth hormone rather than supplying growth hormone directly, which leaves the somatostatin feedback loop intact. EMD Serono sold it as Geref for treating idiopathic growth hormone deficiency in children and as Geref Diagnostic for pituitary testing; both were discontinued in 2008 for commercial reasons, and the FDA determined in 2013 that neither had been withdrawn for safety or effectiveness. There is now no approved sermorelin product in the United States or the European Union, and all current adult use is off-label prescribing of compounded material for body composition, sleep and longevity, none of which has been tested in a controlled trial.
- Formula
- C149 H246 N44 O42 S
- Molar mass
- 3,357.9 g/mol
- CAS number
- 86168-78-7
- Amino acids
- 29
Research evidence described in the source
Historical pediatric clinical data
Daily 30 mcg/kg studies reported increased growth velocity in some prepubertal children.
Diagnostic and treatment review
The evidence base is old, indication-specific, and does not establish final-height superiority.
Limited older-adult studies
Small studies measured endocrine and body-composition biomarkers rather than long-term clinical outcomes.
Limitations noted in the source
- The former approved product was discontinued; compounded preparations differ in oversight.
- Pediatric weight-based evidence does not validate fixed adult wellness doses.
- A calculator preset is a recorded research convention, not a recommendation or evidence of clinical benefit.
- Identity, purity, sterility, and stability can vary substantially outside regulated manufacturing.
Publications and references linked by the source
- pubchem.ncbi.nlm.nih.gov/compound/16132413
- pubmed.ncbi.nlm.nih.gov/8772599/
- www.accessdata.fda.gov/drugsatfda_docs/nda/pre96/019863_S001_GEREF.pdf
- www.federalregister.gov/documents/2013/03/04/2013-04827/determination-that-geref-sermorelin-acetate-injection-05-milligrams-basevial-and-10-milligrams
- pubmed.ncbi.nlm.nih.gov/9005976/
- pubmed.ncbi.nlm.nih.gov/9141536/
- pmc.ncbi.nlm.nih.gov/articles/PMC2699646/
Background is reproduced from Peptides Calculator with attribution. The source describes compound-level research. It does not evaluate the identity, quality or suitability of a listed supplier’s product or batch.