PNC-27 prices

FROM PEPTIDES CALCULATOR

About PNC-27

Source profile reviewed 2026-10-01 · Imported 2026-10-22. Read the full compound profile

PNC-27 is a 32-amino-acid synthetic peptide that joins residues 12 to 26 of the human p53 tumour suppressor, the part that binds the HDM-2 (MDM2) protein, to penetratin, a membrane residency sequence from the Antennapedia protein. Groups at SUNY Downstate, Drexel and collaborating institutions report that cancer cells carry HDM-2 in their plasma membrane while untransformed cells do not, and that PNC-27 binds that membrane HDM-2 and forms pores, killing the cell by necrosis rather than apoptosis; cells engineered to display HDM-2 on their surface became susceptible. The compound has been tested in cancer cell lines, patient-derived ovarian tumour cells and mouse leukaemia models, but never in a human trial, and several of its investigators hold patents or company positions. In January 2017 the FDA warned consumers not to buy or use PNC-27 as a cancer treatment after finding the bacterium Variovorax paradoxus in a sample of an inhalation solution sold online.

Formula

C188 H293 N53 O44 S

Molar mass

4,032 g/mol

CAS number

1159861-00-3

Amino acids

32

Research evidence described in the source

Limitations noted in the source

• Individual claims and source links have not yet completed editorial verification.
• Evidence level, applicable study model, formulation, route and population remain unassigned.

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